The risk of experiencing flumazenil-induced withdrawal depends on how long you’ve been taking benzos and if your body is physically dependent. High doses and long-term benzodiazepine use increase the risk of experiencing seizures during withdrawal.ĭuring benzo withdrawal, you may also experience the following symptoms: When someone overdoses on benzos and is given flumazenil, they may be irritable and anxious when they regain consciousness.īenzo withdrawal can be dangerous and may cause seizures in some people. Withdrawal can also be instigated by the use of flumazenil because it stops the effects of the drug. Once your body becomes physically dependent on benzos, you will likely experience withdrawal if you suddenly stop taking them. Benzo Withdrawal Syndromeīenzos are recommended for short-term treatment because of the high risk of dependence and withdrawal syndrome. Some people use benzos as anticonvulsants, which also increases the risk of experiencing seizures upon withdrawal. In addition, people who are physically dependent on benzodiazepines may have an increased risk of experiencing immediate withdrawal symptoms after receiving flumazenil. Possible side effects following flumazenil administration include: z-drugs (sedative-hypnotics like Ambien)Īlthough flumazenil is beneficial for reversing a benzo overdose, there is a risk of experiencing adverse events.The following drugs can cause similar overdose symptoms but cannot be treated with flumazenil: If an overdose is caused by multiple drugs, flumazenil will not work. However, benzos are commonly combined with other depressant drugs. Mixed Overdoseįlumazenil works effectively on drug overdoses that are caused by benzodiazepines. However, repeated dosing may occur if the person does not regain consciousness.įlumazenil may have a duration of action of up to 50 minutes, depending on the amount of benzos in the body. Most people respond within the first three minutes of receiving the medication. The drug may take up two minutes to improve symptoms of benzodiazepine toxicity. In addition to flumazenil, healthcare clinicians may also intubate the person to help open the airway and assist breathing. midazolam (used for sedation in surgery)įlumazenil is given as an intravenous (IV) infusion that inhibits the activity of benzos and reverses the binding of benzos from benzodiazepine receptors.It can also be used to reverse the postoperative effects of benzos that are used as anesthetics. Treating A Benzo Overdose With Flumazenilįlumazenil, also known as Romazicon, is a benzodiazepine antagonist, which means it reverses and blocks the effects of benzodiazepine agonists. If you suspect a loved one of experiencing a benzodiazepine overdose, seek medical attention immediately. Respiratory depression is characterized by slowed breathing and can be life-threatening if untreated.Īlong with difficulty breathing, other signs of a benzo overdose may include: When taken in high doses, benzos can cause severe respiratory depression. These functions include breathing, heart rate, and blood pressure. However, benzos are central nervous system (CNS) depressants that slow the body’s functions. This helps increase relaxation and reduce symptoms related to anxiety and insomnia. Causes Of Benzodiazepine Overdoseīenzodiazepines (benzos) increase the neurotransmitter gamma-aminobutyric acid (GABA) after binding to benzodiazepine receptors in the brain. Flumazenil works as an antidote by inhibiting the effects of benzodiazepines on the central nervous system. Although they are generally safe to take as prescribed, large doses can result in a benzodiazepine overdose.įlumazenil is an FDA-approved medication used by medical professionals that can reverse the effects of a benzodiazepine overdose. Secular Organizations For Sobriety (SOS)īenzodiazepines are a class of prescription drugs commonly used to treat anxiety and insomnia disorders.Eye Movement Desensitization & Reprocessing (EMDR).Drug Abuse Resources For College Students.Substance Abuse Resources For People With Disabilities.Resources For Minorities Experiencing Treatment Disparities.Complete Guide For People Facing Drug Charges.COVID-19 Mental Health And Addiction Resources.
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